🏳️UniProt

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UniProt is the world’s leading high-quality, comprehensive and freely accessible resource of protein sequence and functional information.

UniProt website home page

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Find your protein

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UniProtKB

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Examples: Insulin, APP, Human, P05067, organism\_id:9606

[UniProt](/help/about) is the world’s leading high-quality, comprehensive and freely accessible resource of protein sequence and functional information. [Cite UniProt](/help/publications) 

UniProt core data

-----------------

[](/uniprotkb "UniProt Knowledgebase, protein database")

### Proteins

#### UniProt Knowledgebase

[

Reviewed

(Swiss-Prot)

572,970

](/uniprotkb?query=reviewed:true "UniProt Knowledgebase, SwissProt or reviewed protein database")[

Unreviewed

(TrEMBL)

252,633,200

](/uniprotkb?query=reviewed:false "UniProt Knowledgebase, TrEMBL or unreviewed protein database")

[](/proteomes "UniProt Proteomes, database of protein sets from genomes")

### Species

#### Proteomes

Protein sets for species with sequenced genomes from across the tree of life

[](/uniref "UniRef, database of protein clustered by identity")

### Protein Clusters

#### UniRef

Clusters of protein sequences at 100%, 90% & 50% identity

[](/uniparc "UniParc, database of protein sequences")

### Sequence archive

#### UniParc

Non-redundant archive of publicly available protein sequences seen across different databases

Supporting Data

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[Taxonomy](/taxonomy?query=*)

[Keywords](/keywords?query=*)

[Literature Citations](/citations?query=*)

[Human diseases](/diseases?query=*)

[Cross-referenced databases](/database?query=*)

[Subcellular locations](/locations?query=*)

Automatic annotations: [UniRule](/unirule?query=*) & [ARBA](/arba?query=*)

Latest News

-----------

[View release archive](/release-notes)

*   ### [Forthcoming changes](/release-notes/forthcoming-changes)

    Planned changes for UniProt

*   ### [UniProt release 2025\_01](/release-notes/2025-02-05-release)

    The 'dark' side of male contraception | Changes to the controlled vocabulary of human diseases | Changes to the...

*   ### [UniProt release 2024\_06](/release-notes/2024-11-27-release)

    What happens when ribosomes crash | Cross-references to FunFam | Cross-references to AntiFam

*   ### [UniProt release 2024\_05](/release-notes/2024-10-02-release)

    Plasma membrane rupture during cell death: from a passive hypothesis to an active process | Changes to the controlled vocabulary of human diseases

*   ### [UniProt release 2024\_04](/release-notes/2024-07-24-release)

    Oocyte waste disposal strategy: 'store to degrade later' | Removal of the cross-references to CLAE | Removal of the cross-references to COMPLUYEAST-2DPAGE

*   ### [UniProt release 2024\_03](/release-notes/2024-05-29-release)

    The culprit for extreme morning sickness identified | Removal of the cross-references to Genevisible | Removal of the cross-references to SWISS-2DPAGE

*   ### [UniProt release 2024\_02](/release-notes/2024-03-27-release)

    CMV infections: plants beaten at their own game | Changes to the controlled vocabulary of human diseases | Changes to the controlled vocabulary for PTMs

[](https://insideuniprot.blogspot.com/2023/05/usinguniprot-discanvis-interpreting.html)

### [#UsingUniProt - DisCanVis interpreting genomic variation data](https://insideuniprot.blogspot.com/2023/05/usinguniprot-discanvis-interpreting.html)

In recent years a wealth of information has become available about genetic variations that underlie various diseases, especially cancer.

[](http://insideuniprot.blogspot.com/2022/12/how-artificial-intelligence-can-help-us.html)

### [How artificial intelligence can help us annotate protein names](http://insideuniprot.blogspot.com/2022/12/how-artificial-intelligence-can-help-us.html)

A conversation with machine learning engineer Andreea Gane. At UniProt we are very interested in engaging with the machine learning community

[protein spotlight](https://www.proteinspotlight.org)

### [The dormant ribosome](https://www.proteinspotlight.org/back_issues/277/)

[](https://www.proteinspotlight.org/back_issues/277/)

Snowdrops are here. The tips of daffodil shoots are pushing through the soil, and soft grey buds are preparing to burst on the magnolias. These are reminders that winter marks the end of one life cycle while spring marks the one about to begin...

Analysis Tools

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[View dashboard](/tool-dashboard)

[](/blast)

### BLAST

Search with a sequence to find homologs through pairwise sequence alignment

[](/align)

### Align

Align two or more protein sequences with Clustal Omega to find conserved regions

[](/id-mapping)

### Search with Lists Map IDs

Find proteins with lists of UniProt IDs or convert from/to other database IDs

[](/peptide-search)

### Search Peptides

Search with a peptide sequence to find all UniProt proteins that contain exact matches

Need help?

----------

Find answers through our help center or get in touch

[Help center](/help) [Contact us](/contact)  

[](https://www.linkedin.com/company/uniprot/ "UniProt posts on LinkedIn")[](https://x.com/uniprot "UniProt posts on X (formerly Twitter)")

### Attend training

[European Bioinformatics Institute (EBI)](https://www.ebi.ac.uk/training/)[Protein Information Resource (PIR)](https://proteininformationresource.org/training/)[Swiss Institute of Bioinformatics (SIB)](https://www.sib.swiss/training/upcoming-training-courses)

[Tutorial & videos](https://www.youtube.com/c/uniprotvideos/featured) [Online courses](https://www.ebi.ac.uk/training/search-results?query=uniprot&domain=ebiweb_training&page=1&facets=)

### Live webinar

Open 5 June 2025Online

#### [From sequences to structures](https://www.ebi.ac.uk/training/events/sequences-structures)

Proteins are fundamental to biological processes, and understanding their sequence, structure, and function is crucial for various applications in research. This one-day, hands-on virtual workshop will guide participants through a structured, programmatic workflow using EMBL-EBI resources. Participants will learn how to retrieve protein sequences, identify homologs, annotate functional domains, and explore structural information using REST APIs. The course emphasises programmatic access (APIs) to integrate sequence, functional, and structural data into a unified analysis pipeline. Through a step-by-step Python workflow, participants will apply different EMBL-EBI tools to analyse an example protein, gaining practical experience in automating large-scale protein data analysis.Virtual courseThis course will take place on Zoom. Trainers will be available to assist during practical sessions, answer questions, and provide further explanations during the Zoom.To join the course you will need to create an EMBL-EBI Training website account.

UniProt data

------------

[](https://ftp.uniprot.org/pub/databases/uniprot/)

### FTP Download

Download UniProt release data

[](/help/technical)

### Technical Documentation

Manuals, schemas and ontology descriptions

[](/help/programmatic_access)

### Programmatic Access

Query UniProt data using APIs providing REST, SPARQL and Java services

[](/help/submissions)

### Submit Data

Submit your sequences, publications and annotation updates

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