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**Broad is** accelerating discovery
===================================
Broad Institute is a multidisciplinary community of researchers on a mission to improve human health.
[About us](/about-broad-institute)
Latest
------
[](https://www.broadinstitute.org/news/new-technology-puts-spatial-lens-crispr-screening)
[News 03.12.2025](/news/new-technology-puts-spatial-lens-crispr-screening)
[New technology puts a spatial lens on CRISPR screening](/news/new-technology-puts-spatial-lens-crispr-screening)
Perturb-FISH reveals impacts of perturbations on gene expression and phenotype with single-cell, spatial resolution, allowing study of effects within and between cells.
[News 03.11.2025](/news/count-me-launches-new-patient-partnered-research-project-translocation-renal-cell-carcinoma)
[Count Me In launches new patient-partnered research project for translocation renal cell carcinoma](/news/count-me-launches-new-patient-partnered-research-project-translocation-renal-cell-carcinoma)
[](https://www.broadinstitute.org/news/count-me-launches-new-patient-partnered-research-project-translocation-renal-cell-carcinoma)
[News 03.06.2025](/news/studies-reveal-new-genetic-roots-atrial-fibrillation)
[Studies reveal new genetic roots of atrial fibrillation](/news/studies-reveal-new-genetic-roots-atrial-fibrillation)
[](https://www.broadinstitute.org/news/studies-reveal-new-genetic-roots-atrial-fibrillation)
[News 02.27.2025](/news/ancient-rna-guided-system-could-simplify-delivery-gene-editing-therapies)
[An ancient RNA-guided system could simplify delivery of gene editing therapies](/news/ancient-rna-guided-system-could-simplify-delivery-gene-editing-therapies)
[](https://www.broadinstitute.org/news/ancient-rna-guided-system-could-simplify-delivery-gene-editing-therapies)
[All news](/news)
Our community
-------------
[Join Broad](/join-broad)
We are a research organization dedicated to understanding the roots of disease and closing the gap between new biological insights and impact for patients.
[Institute Members](/modal_paragraph/4506)
[Associate and Affiliate Members](/modal_paragraph/4505)
[Professional scientists](/modal_paragraph/4507)
[Early career scientists](/modal_paragraph/4513)
[Administration](/modal_paragraph/4512)
[Affinity groups](/modal_paragraph/4480)
[Partner institutions](/modal_paragraph/4508)
[How we work](/modal_paragraph/4482)
Research
--------
[Disease areas](#tab-4409) [Research areas](#tab-4414) [Technology areas](#tab-4420)
[](https://www.broadinstitute.org/rare-disease)
Rare disease
Our scientists search for the risk factors underlying rare genetic diseases to help reveal their biological underpinnings and improve patients' lives.
[/rare-disease](/rare-disease)
[](https://www.broadinstitute.org/cancer)
Cancer
Our scientists are probing the mechanisms of cancer and applying this knowledge to enable precision cancer medicine.
[/cancer](/cancer)
[](https://www.broadinstitute.org/cardiovascular-disease)
Cardiovascular disease
By applying a variety of tools and technologies, researchers here are working to reduce the burden of cardiovascular disease.
[/cardiovascular-disease](/cardiovascular-disease)
[](https://www.broadinstitute.org/diabetes)
Diabetes
Our researchers study the cellular roles and physiological impacts of genes associated with type 2 diabetes.
[/diabetes](/diabetes)
[](https://www.broadinstitute.org/infectious-disease-microbiome)
Infectious disease and the microbiome
Researchers across the institute are working to understand infectious diseases, antibiotic resistance, and the human microbiome.
[/infectious-disease-microbiome](/infectious-disease-microbiome)
[](https://www.broadinstitute.org/kidney-disease)
Kidney disease
Our scientists are cataloging the molecular causes of kidney diseases in order to develop mechanism-based treatments.
[/kidney-disease](/kidney-disease)
[](https://www.broadinstitute.org/obesity)
Obesity
By studying the genetic determinants of body weight, our researchers work to identify targets for future obesity therapies.
[/obesity](/obesity)
[](https://www.broadinstitute.org/brain-health)
Brain health
We are characterizing the genetic and mechanistic basis of brain health and brain diseases.
[/brain-health](/brain-health)
[](https://www.broadinstitute.org/rare-disease)
Rare disease
Our scientists search for the risk factors underlying rare genetic diseases to help reveal their biological underpinnings and improve patients' lives.
[/rare-disease](/rare-disease)
[](https://www.broadinstitute.org/cancer)
Cancer
Our scientists are probing the mechanisms of cancer and applying this knowledge to enable precision cancer medicine.
[/cancer](/cancer)
[](https://www.broadinstitute.org/cardiovascular-disease)
Cardiovascular disease
By applying a variety of tools and technologies, researchers here are working to reduce the burden of cardiovascular disease.
[/cardiovascular-disease](/cardiovascular-disease)
[](https://www.broadinstitute.org/diabetes)
Diabetes
Our researchers study the cellular roles and physiological impacts of genes associated with type 2 diabetes.
[/diabetes](/diabetes)
[](https://www.broadinstitute.org/infectious-disease-microbiome)
Infectious disease and the microbiome
Researchers across the institute are working to understand infectious diseases, antibiotic resistance, and the human microbiome.
[/infectious-disease-microbiome](/infectious-disease-microbiome)
[](https://www.broadinstitute.org/kidney-disease)
Kidney disease
Our scientists are cataloging the molecular causes of kidney diseases in order to develop mechanism-based treatments.
[/kidney-disease](/kidney-disease)
[](https://www.broadinstitute.org/obesity)
Obesity
By studying the genetic determinants of body weight, our researchers work to identify targets for future obesity therapies.
[/obesity](/obesity)
[](https://www.broadinstitute.org/brain-health)
Brain health
We are characterizing the genetic and mechanistic basis of brain health and brain diseases.
[/brain-health](/brain-health)
[](https://www.broadinstitute.org/rare-disease)
Rare disease
Our scientists search for the risk factors underlying rare genetic diseases to help reveal their biological underpinnings and improve patients' lives.
[/rare-disease](/rare-disease)
[
Cancer
](#tab-4401)[
Cardiovascular disease
](#tab-4402)[
Diabetes
](#tab-4403)[
Infectious disease and the microbiome
](#tab-4404)[
Kidney disease
](#tab-4405)[
Obesity
](#tab-4406)[
Brain health
](#tab-4407)[
Rare disease
](#tab-4408)
[](https://www.broadinstitute.org/metabolism)
Metabolism
Our researchers aim to decipher the metabolic basis of rare and common human diseases.
[/metabolism](/metabolism)
[](https://www.broadinstitute.org/chemical-biology-and-therapeutics-science)
Chemical biology and therapeutics science
We are fostering a diverse research community engaged in innovative chemical biology and therapeutic research.
[/chemical-biology-and-therapeutics-science](/chemical-biology-and-therapeutics-science)
[](https://www.broadinstitute.org/center-development-therapeutics-cdot)
Drug discovery
Our Center for the Development of Therapeutics (CDoT) helps scientists advance biological insights to new treatments.
[/center-development-therapeutics-cdot](/center-development-therapeutics-cdot)
[](https://www.broadinstitute.org/genomeregulation-cellcircuitry-epigenomics)
Genome regulation, cellular circuitry, and epigenomics
Our scientists are charting the vast landscape of molecular elements that define and regulate the cell.
[/genomeregulation-cellcircuitry-epigenomics](/genomeregulation-cellcircuitry-epigenomics)
[](https://www.broadinstitute.org/immunology)
Immunology
Researchers across Broad are defining the immune cells and pathways that regulate physiologic and pathologic processes.
[/immunology](/immunology)
[](https://www.broadinstitute.org/medical-population-genetics)
Medical and population genetics
An array of scientists here are collaborating to establish genomic variations' roles in human traits and disorders.
[/medical-population-genetics](/medical-population-genetics)
[](https://www.broadinstitute.org/metabolism)
Metabolism
Our researchers aim to decipher the metabolic basis of rare and common human diseases.
[/metabolism](/metabolism)
[](https://www.broadinstitute.org/chemical-biology-and-therapeutics-science)
Chemical biology and therapeutics science
We are fostering a diverse research community engaged in innovative chemical biology and therapeutic research.
[/chemical-biology-and-therapeutics-science](/chemical-biology-and-therapeutics-science)
[](https://www.broadinstitute.org/center-development-therapeutics-cdot)
Drug discovery
Our Center for the Development of Therapeutics (CDoT) helps scientists advance biological insights to new treatments.
[/center-development-therapeutics-cdot](/center-development-therapeutics-cdot)
[](https://www.broadinstitute.org/genomeregulation-cellcircuitry-epigenomics)
Genome regulation, cellular circuitry, and epigenomics
Our scientists are charting the vast landscape of molecular elements that define and regulate the cell.
[/genomeregulation-cellcircuitry-epigenomics](/genomeregulation-cellcircuitry-epigenomics)
[](https://www.broadinstitute.org/immunology)
Immunology
Researchers across Broad are defining the immune cells and pathways that regulate physiologic and pathologic processes.
[/immunology](/immunology)
[](https://www.broadinstitute.org/medical-population-genetics)
Medical and population genetics
An array of scientists here are collaborating to establish genomic variations' roles in human traits and disorders.
[/medical-population-genetics](/medical-population-genetics)
[](https://www.broadinstitute.org/metabolism)
Metabolism
Our researchers aim to decipher the metabolic basis of rare and common human diseases.
[/metabolism](/metabolism)
[
Chemical biology and therapeutics science
](#tab-4410)[
Drug discovery
](#tab-4411)[
Genome regulation, cellular circuitry, and epigenomics
](#tab-4412)[
Immunology
](#tab-4413)[
Medical and population genetics
](#tab-4477)[
Metabolism
](#tab-4478)
[](https://www.broadinstitute.org/spatial-technology-platform)
Spatial technologies
The Spatial Technology Platform expands the impact of spatial -omics through comprehensive support – from study design to data acquisition and processing – for a broad range of users. We also maintain an active research arm that develops and advances cutting edge spatial, imaging, and computational technologies.
[/spatial-technology-platform](/spatial-technology-platform)
[](https://www.broadinstitute.org/data-sciences)
Data sciences
Members of the Data Sciences Platform build open-source technologies that help researchers everywhere connect to the patients, datasets, and tools they need to do life-changing science.
[/data-sciences](/data-sciences)
[](https://www.broadinstitute.org/genetic-perturbation-platform)
Genetic perturbation
The Genetic Perturbation Platform drives the functional study of the genome by developing groundbreaking technologies for perturbing genes at scale.
[/genetic-perturbation-platform](/genetic-perturbation-platform)
[](https://www.broadinstitute.org/genomics)
Genomics
Genomic scientists here at Broad create foundational resources and study the genomic basis of human traits and diseases.
[/genomics](/genomics)
[](https://www.broadinstitute.org/imaging)
Imaging
Computationally mining cellular images' rich information content can propel discoveries in biology and medicine.
[/imaging](/imaging)
[](https://www.broadinstitute.org/metabolomics)
Metabolomics
Cells' metabolites reveal unique chemical fingerprints of both normal and pathological disease processes.
[/metabolomics](/metabolomics)
[](https://www.broadinstitute.org/proteomics)
Proteomics
Broad proteomic researchers address important questions in biology, chemistry, and clinical science through collaboration and technology development.
[/proteomics](/proteomics)
[](https://www.broadinstitute.org/spatial-technology-platform)
Spatial technologies
The Spatial Technology Platform expands the impact of spatial -omics through comprehensive support – from study design to data acquisition and processing – for a broad range of users. We also maintain an active research arm that develops and advances cutting edge spatial, imaging, and computational technologies.
[/spatial-technology-platform](/spatial-technology-platform)
[](https://www.broadinstitute.org/data-sciences)
Data sciences
Members of the Data Sciences Platform build open-source technologies that help researchers everywhere connect to the patients, datasets, and tools they need to do life-changing science.
[/data-sciences](/data-sciences)
[](https://www.broadinstitute.org/genetic-perturbation-platform)
Genetic perturbation
The Genetic Perturbation Platform drives the functional study of the genome by developing groundbreaking technologies for perturbing genes at scale.
[/genetic-perturbation-platform](/genetic-perturbation-platform)
[](https://www.broadinstitute.org/genomics)
Genomics
Genomic scientists here at Broad create foundational resources and study the genomic basis of human traits and diseases.
[/genomics](/genomics)
[](https://www.broadinstitute.org/imaging)
Imaging
Computationally mining cellular images' rich information content can propel discoveries in biology and medicine.
[/imaging](/imaging)
[](https://www.broadinstitute.org/metabolomics)
Metabolomics
Cells' metabolites reveal unique chemical fingerprints of both normal and pathological disease processes.
[/metabolomics](/metabolomics)
[](https://www.broadinstitute.org/proteomics)
Proteomics
Broad proteomic researchers address important questions in biology, chemistry, and clinical science through collaboration and technology development.
[/proteomics](/proteomics)
[](https://www.broadinstitute.org/spatial-technology-platform)
Spatial technologies
The Spatial Technology Platform expands the impact of spatial -omics through comprehensive support – from study design to data acquisition and processing – for a broad range of users. We also maintain an active research arm that develops and advances cutting edge spatial, imaging, and computational technologies.
[/spatial-technology-platform](/spatial-technology-platform)
[
Data sciences
](#tab-4415)[
Genetic perturbation
](#tab-4416)[
Genomics
](#tab-4417)[
Imaging
](#tab-4418)[
Metabolomics
](#tab-4419)[
Proteomics
](#tab-4479)[
Spatial technologies
](#tab-19046)
[
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Today, on International Day of Women and Girls in Science, we celebrate the countless contributions of #WomenInScience. Their work advances scientific discovery, drives innovation, and empowers the next generation of scientists. Thank you for shaping the future of science! #InternationalDayOfWomenAndGirlsInScience #BroadInstitute
Today, on International Day of Women and Girls in Science, we celebrate the countless contributions of #WomenInScience. Their work advances scientific discovery, drives innovation, and empowers the next generation of scientists. Thank you for shaping the future of science! #InternationalDayOfWomenAndGirlsInScience #BroadInstitute
](https://www.instagram.com/p/DF8C9IQRIPa)
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Likes Count
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“Aorta” tell you how to celebrate Valentine’s Day with the Broad Institute! Join us at the Broad Discovery Center on Friday, February 14th, anytime between 10 am - 5 pm to make a science-themed valentine and enjoy sweet treats! Free, all ages, and open to the public. Learn more at the link in our bio.
“Aorta” tell you how to celebrate Valentine’s Day with the Broad Institute! Join us at the Broad Discovery Center on Friday, February 14th, anytime between 10 am - 5 pm to make a science-themed valentine and enjoy sweet treats! Free, all ages, and open to the public. Learn more at the link in our bio.
](https://www.instagram.com/p/DFvYcbDx1Zo)
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Celebrate Valentine’s Day at the Broad Discovery Center! Join us on Friday, February 14 anytime between 10 am - 5 pm. Make a science-themed valentine and enjoy a sweet treat! Free, all ages, and open to the public.
Celebrate Valentine’s Day at the Broad Discovery Center! Join us on Friday, February 14 anytime between 10 am - 5 pm. Make a science-themed valentine and enjoy a sweet treat! Free, all ages, and open to the public.
](https://www.instagram.com/p/DFqDmbvxmqS)
[
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Visualizing cells after editing specific genes can help scientists learn new details about the function of those genes. But using microscopy to do this at scale can be challenging, particularly when studying thousands of genes at a time. PERISCOPE, a new technique for genome-wide imaging screens, could help scientists understand the connections between genes and traits. Discover more by using the link in our bio. #BroadInstitute #CRISPR #Science
Visualizing cells after editing specific genes can help scientists learn new details about the function of those genes. But using microscopy to do this at scale can be challenging, particularly when studying thousands of genes at a time. PERISCOPE, a new technique for genome-wide imaging screens, could help scientists understand the connections between genes and traits. Discover more by using the link in our bio. #BroadInstitute #CRISPR #Science
](https://www.instagram.com/p/DFVqffNRfgH)
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Likes Count
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Huntington’s disease is a devastating disorder, but new research offers promising progress toward treatment — progress that’s possible thanks to the generosity of brain donors and their families. Associate member Sabina Berretta highlights how their invaluable contributions advance scientific discovery. Learn more at the link in our bio.
Huntington’s disease is a devastating disorder, but new research offers promising progress toward treatment — progress that’s possible thanks to the generosity of brain donors and their families. Associate member Sabina Berretta highlights how their invaluable contributions advance scientific discovery. Learn more at the link in our bio.
](https://www.instagram.com/p/DFN23zux1cG)
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A new study reveals the surprising mechanism by which a genetic mutation causes Huntington’s disease. Hear from institute member Steve McCarroll about how understanding of the disease has evolved, leading to this discovery that could help shape future treatment strategies. Learn more at the link in our bio. #BroadInstitute
A new study reveals the surprising mechanism by which a genetic mutation causes Huntington’s disease. Hear from institute member Steve McCarroll about how understanding of the disease has evolved, leading to this discovery that could help shape future treatment strategies. Learn more at the link in our bio. #BroadInstitute
](https://www.instagram.com/p/DFF-ByZRRl3)
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Scientists have discovered a surprising mechanism by which an inherited genetic mutation causes Huntington’s disease. For 30 years, researchers have known that Huntington’s is caused by an inherited mutation in the HTT gene, but they didn’t know how the mutation causes brain cell death. Now, new findings change the understanding of the fatal neurodegenerative disorder and suggest potential ways to delay or even prevent it. Learn more at the link in our bio. #BroadInstitute
Scientists have discovered a surprising mechanism by which an inherited genetic mutation causes Huntington’s disease. For 30 years, researchers have known that Huntington’s is caused by an inherited mutation in the HTT gene, but they didn’t know how the mutation causes brain cell death. Now, new findings change the understanding of the fatal neurodegenerative disorder and suggest potential ways to delay or even prevent it. Learn more at the link in our bio. #BroadInstitute
](https://www.instagram.com/p/DE5Jw-oRzNN)
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Clinical genomicist Heidi Rehm has spent more than two decades doing everything she can to bring better care to patients. Her fingerprints can be found on many of the standards and tools that have allowed clinical geneticists to increase their diagnostic success rate over the years. “There are so many inefficiencies in how we learn about a person’s genetics, and that’s not all going to change overnight,” she said. “But gathering the collective intelligence, drive, and effort of the community is going to allow us to do something that is greater than the sum of its parts.” Learn more about Rehm’s background as an organizer and community builder in a new Broad feature story. Learn more at the link in our bio.
Clinical genomicist Heidi Rehm has spent more than two decades doing everything she can to bring better care to patients. Her fingerprints can be found on many of the standards and tools that have allowed clinical geneticists to increase their diagnostic success rate over the years. “There are so many inefficiencies in how we learn about a person’s genetics, and that’s not all going to change overnight,” she said. “But gathering the collective intelligence, drive, and effort of the community is going to allow us to do something that is greater than the sum of its parts.” Learn more about Rehm’s background as an organizer and community builder in a new Broad feature story. Learn more at the link in our bio.
](https://www.instagram.com/p/DEiLV-fxgXJ)
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Broad Discovery Series: Introducing the immune system, and expanding its cancer-fighting potential
[Take a brief tour of the immune system with cancer immunologist Lloyd Bod, and learn how we might better harness it to fight cancer.](/broad-discovery-series)
Visit the Broad Discovery Center
[Explore exhibits showcasing how scientists are advancing our understanding of disease. The museum is in the ground floor atrium of the Merkin building at 415 Main Street, Cambridge, MA and is free and open to the public.](https://broaddiscoverycenter.org)
Learn about summer research programs for students
[Watch a video to see how high school and undergraduate students have benefitted from doing summer research at Broad.](https://www.youtube.com/watch?v=ptpNUcmiVsg)
The Body Works: Love Letters from The Peoples’ heART
[Visit this art exhibit in the lobby of the Stanley building at 75 Ames Street, Cambridge, MA until April 25, 2025.](/community/gallery-program)